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PULSe Home > Faculty Members A-C > Donald Bergstrom
Donald E. Bergstrom
Current Research Interests:
A major research effort in our laboratory is directed towards re-engineering DNA. The purpose of this work is primarily to construct modified nucleic acids for use as biochemical tools, diagnostic probes, or genetically targeted drugs. This research requires the design and synthesis of nucleic acid components (nucleosides) which can be incorporated into nucleic acids by automated synthesis. Two recent accomplishments in our laboratory include the discovery of a series of five membered ring derived nucleoside analogs which, when incorporated into DNA, function as wild cards, and completion of a study on the effects of pyrimidine C5 substitution on duplex DNA stability in order to optimize tethers for appending probes and other functional groups to synthetic nucleic acids.
Selected Publications:
Samir M. Iqbal, G. Balasundaram, Subhasis Ghosh, D. E. Bergstrom and R. Bashir, "Direct current electrical measurement of dsDNA in nanogap junctions", Applied Physics Letters 2005, 86, 153901.
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